Optimization Methods in Metabolic Networks

Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks <br /> <ul> <li>Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis</li> <li>Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP</li> <li>Explains the most efficient ways of formulating a biological problem using mathematical optimization</li> <li>Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations</li> <li>Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems</li> </ul>